Drug interactions
Ceritinib + Medroxyprogesterone
Severity: Minor
Ceritinib and Medroxyprogesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may raise medroxyprogesterone exposure. Progestin adverse effects could be increased, although the clinical importance is uncertain.
What this interaction means in plain words
Ceritinib and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ceritinib belongs to Oncology; Medroxyprogesterone belongs to Endocrine.
Why it happens
Ceritinib inhibits CYP3A4 metabolism of medroxyprogesterone.
What to do
Monitor for progestogenic adverse effects such as bleeding changes and fluid retention; no empirical dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ceritinib and Medroxyprogesterone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Medroxyprogesterone
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Medroxyprogesterone?
MediHelp rates the interaction as minor. Ceritinib and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceritinib inhibits CYP3A4 and may raise medroxyprogesterone exposure. Progestin adverse effects could be increased, although the clinical importance is uncertain.
How serious is the interaction between Ceritinib and Medroxyprogesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestogenic adverse effects such as bleeding changes and fluid retention; no empirical dose change is required.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
