Drug interactions
Ceritinib + Propofol
Severity: Minor
Ceritinib and Propofol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP2C9 in vitro, but propofol is cleared mainly by glucuronidation with minor CYP2B6 and CYP2C9 involvement. A clinically meaningful rise in propofol levels is not expected.
What this interaction means in plain words
Ceritinib and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ceritinib belongs to Oncology; Propofol belongs to Central Nervous System.
Why it happens
Theoretical minor CYP2C9 inhibition; propofol is predominantly glucuronidated.
What to do
No dose change is routinely needed; titrate propofol to clinical effect as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propofol
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Propofol?
MediHelp rates the interaction as minor. Ceritinib and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ceritinib inhibits CYP2C9 in vitro, but propofol is cleared mainly by glucuronidation with minor CYP2B6 and CYP2C9 involvement. A clinically meaningful rise in propofol levels is not expected.
How serious is the interaction between Ceritinib and Propofol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; titrate propofol to clinical effect as usual.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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