Drug interactions
Cetirizine + Metoclopramide
Severity: Minor
Cetirizine and Metoclopramide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cetirizine is mildly sedating in some patients, and metoclopramide can also cause somnolence and fatigue. Combined use may increase drowsiness, though the clinical effect is usually modest.
What this interaction means in plain words
Cetirizine and Metoclopramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cetirizine belongs to Respiratory; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system sedative effects.
What to do
Advise the patient about possible drowsiness and caution with driving. No dose change is usually needed unless sedation is troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoclopramide
Other interactions of Cetirizine
- Acrivastine + Cetirizine Moderate
- Amisulpride + Cetirizine Moderate
- Asenapine + Cetirizine Moderate
- Avapritinib + Cetirizine Moderate
- Benzhydrocodone / acetaminophen + Cetirizine Moderate
- Brexpiprazole + Cetirizine Moderate
Frequently asked questions
Can I take Cetirizine with Metoclopramide?
MediHelp rates the interaction as minor. Cetirizine and Metoclopramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cetirizine is mildly sedating in some patients, and metoclopramide can also cause somnolence and fatigue. Combined use may increase drowsiness, though the clinical effect is usually modest.
How serious is the interaction between Cetirizine and Metoclopramide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient about possible drowsiness and caution with driving. No dose change is usually needed unless sedation is troublesome.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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