Drug interactions
Cetirizine + Tepotinib
Severity: Minor
Cetirizine and Tepotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-glycoprotein and may raise cetirizine exposure. Given cetirizine's wide safety margin, the expected effect is mild, mainly more drowsiness.
What this interaction means in plain words
Cetirizine and Tepotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cetirizine belongs to Respiratory; Tepotinib belongs to Oncology.
Why it happens
P-glycoprotein inhibition by tepotinib reduces cetirizine efflux.
What to do
No dose change is routinely required. Monitor for sedation and lower the cetirizine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cetirizine
- Acrivastine + Cetirizine Moderate
- Amisulpride + Cetirizine Moderate
- Asenapine + Cetirizine Moderate
- Avapritinib + Cetirizine Moderate
- Benzhydrocodone / acetaminophen + Cetirizine Moderate
- Brexpiprazole + Cetirizine Moderate
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Cetirizine with Tepotinib?
MediHelp rates the interaction as minor. Cetirizine and Tepotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tepotinib inhibits P-glycoprotein and may raise cetirizine exposure. Given cetirizine's wide safety margin, the expected effect is mild, mainly more drowsiness.
How serious is the interaction between Cetirizine and Tepotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely required. Monitor for sedation and lower the cetirizine dose if needed.
What other medicines interact with Cetirizine?
MediHelp also lists interactions of Cetirizine with, for example, Acrivastine, Amisulpride, Asenapine. The full list is on the Cetirizine page.
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