Drug interactions
Chloroquine + Enzalutamide
Severity: Minor
Chloroquine and Enzalutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and may reduce chloroquine concentrations, since CYP3A4 contributes to its metabolism. Chloroquine's clearance is only partly CYP-dependent, so the effect on efficacy is uncertain, but reduced antimalarial exposure is possible. Both drugs can also affect QT, though enzalutamide has a lesser effect.
What this interaction means in plain words
Chloroquine and Enzalutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloroquine belongs to Anti Parasitic; Enzalutamide belongs to Endocrine.
Why it happens
Induction of CYP3A4 by enzalutamide may increase chloroquine metabolism.
What to do
No routine dose change is needed. Monitor for reduced response when chloroquine is used for treatment or prophylaxis over prolonged periods.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Chloroquine with Enzalutamide?
MediHelp rates the interaction as minor. Chloroquine and Enzalutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Enzalutamide is a strong CYP3A4 inducer and may reduce chloroquine concentrations, since CYP3A4 contributes to its metabolism. Chloroquine's clearance is only partly CYP-dependent, so the effect on efficacy is uncertain, but reduced antimalarial exposure is possible. Both drugs can also affect QT, though enzalutamide has a lesser effect.
How serious is the interaction between Chloroquine and Enzalutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for reduced response when chloroquine is used for treatment or prophylaxis over prolonged periods.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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