Drug interactions
Chloroquine + Leuprolide
Severity: Moderate
Chloroquine and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with leuprolide can lengthen the QT interval, and chloroquine does the same. Combined use increases the risk of torsades de pointes, especially with electrolyte disturbance or heart disease.
What this interaction means in plain words
Chloroquine and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Leuprolide belongs to Endocrine.
Why it happens
Additive prolongation of cardiac repolarization (QTc) by both drugs.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Repeat ECG monitoring during co-therapy and consider alternatives in patients with existing QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Chloroquine with Leuprolide?
MediHelp rates the interaction as moderate. Chloroquine and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation with leuprolide can lengthen the QT interval, and chloroquine does the same. Combined use increases the risk of torsades de pointes, especially with electrolyte disturbance or heart disease.
How serious is the interaction between Chloroquine and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Repeat ECG monitoring during co-therapy and consider alternatives in patients with existing QT prolongation.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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