Drug interactions
Chloroquine + Prochlorperazine
Severity: Moderate
Chloroquine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine may inhibit CYP2D6 and slightly raise prochlorperazine levels. Both drugs can prolong the QT interval, which is the more important concern when they are combined.
What this interaction means in plain words
Chloroquine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chloroquine belongs to Anti Parasitic; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, plus possible weak CYP2D6 inhibition by chloroquine.
What to do
Obtain a baseline ECG and correct potassium and magnesium if the combination is needed. Monitor for palpitations, syncope, and extrapyramidal effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Chloroquine with Prochlorperazine?
MediHelp rates the interaction as moderate. Chloroquine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloroquine may inhibit CYP2D6 and slightly raise prochlorperazine levels. Both drugs can prolong the QT interval, which is the more important concern when they are combined.
How serious is the interaction between Chloroquine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium if the combination is needed. Monitor for palpitations, syncope, and extrapyramidal effects.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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