Drug interactions
Chloroquine + Toremifene
Severity: Major
Chloroquine and Toremifene: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Toremifene prolongs the QT interval in a dose-related way, and chloroquine has a similar effect. The combination increases the risk of torsades de pointes, especially in patients with hypokalemia, hypomagnesemia, bradycardia or congenital long QT.
What this interaction means in plain words
Chloroquine and Toremifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloroquine belongs to Anti Parasitic; Toremifene belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation from blockade of cardiac potassium channels.
What to do
Avoid the combination when possible, since toremifene labeling advises against coadministration with QT-prolonging drugs. If unavoidable, correct electrolytes and monitor ECG closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
Frequently asked questions
Can I take Chloroquine with Toremifene?
MediHelp rates the interaction as major. Chloroquine and Toremifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Toremifene prolongs the QT interval in a dose-related way, and chloroquine has a similar effect. The combination increases the risk of torsades de pointes, especially in patients with hypokalemia, hypomagnesemia, bradycardia or congenital long QT.
How serious is the interaction between Chloroquine and Toremifene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible, since toremifene labeling advises against coadministration with QT-prolonging drugs. If unavoidable, correct electrolytes and monitor ECG closely.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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