Drug interactions
Chlorothiazide + Empagliflozin
Severity: Moderate
Chlorothiazide and Empagliflozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin causes osmotic diuresis and, together with a thiazide diuretic, can increase urine output and sodium loss. This may lead to volume depletion, hypotension, dizziness and acute kidney injury, especially in elderly or renally impaired patients.
What this interaction means in plain words
Chlorothiazide and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Empagliflozin belongs to Endocrine.
Why it happens
Additive diuretic and natriuretic effects at different sites in the nephron.
What to do
Assess volume status and renal function before and after starting empagliflozin, and monitor blood pressure and electrolytes. Consider lowering the diuretic dose if signs of volume depletion appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Empagliflozin?
MediHelp rates the interaction as moderate. Chlorothiazide and Empagliflozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin causes osmotic diuresis and, together with a thiazide diuretic, can increase urine output and sodium loss. This may lead to volume depletion, hypotension, dizziness and acute kidney injury, especially in elderly or renally impaired patients.
How serious is the interaction between Chlorothiazide and Empagliflozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status and renal function before and after starting empagliflozin, and monitor blood pressure and electrolytes. Consider lowering the diuretic dose if signs of volume depletion appear.
What other medicines interact with Empagliflozin?
MediHelp also lists interactions of Empagliflozin with, for example, Amiloride, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Empagliflozin page.
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