Drug interactions
Chlorpromazine + Dantrolene
Severity: Moderate
Chlorpromazine and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine is strongly sedating and, with dantrolene, may cause pronounced drowsiness, hypotension and weakness. Falls and impaired alertness are the main risks.
What this interaction means in plain words
Chlorpromazine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive CNS depression with antihistaminic and alpha-adrenergic blocking effects of chlorpromazine.
What to do
Start with low doses, monitor sedation and blood pressure, and counsel on driving and fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Dantrolene?
MediHelp rates the interaction as moderate. Chlorpromazine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine is strongly sedating and, with dantrolene, may cause pronounced drowsiness, hypotension and weakness. Falls and impaired alertness are the main risks.
How serious is the interaction between Chlorpromazine and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses, monitor sedation and blood pressure, and counsel on driving and fall risk.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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