Drug interactions
Chlorpromazine + Duloxetine
Severity: Moderate
Chlorpromazine and Duloxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine is partly metabolized by CYP2D6, so duloxetine may increase its exposure. Both drugs may also contribute to hypotension and sedation, and chlorpromazine can prolong the QT interval.
What this interaction means in plain words
Chlorpromazine and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Duloxetine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by duloxetine reduces chlorpromazine clearance, with additive CNS and cardiovascular effects.
What to do
Monitor for sedation, orthostatic hypotension and extrapyramidal effects. Consider an ECG in patients with QT risk factors and lower the chlorpromazine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpromazine and Duloxetine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Duloxetine?
MediHelp rates the interaction as moderate. Chlorpromazine and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine is partly metabolized by CYP2D6, so duloxetine may increase its exposure. Both drugs may also contribute to hypotension and sedation, and chlorpromazine can prolong the QT interval.
How serious is the interaction between Chlorpromazine and Duloxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and extrapyramidal effects. Consider an ECG in patients with QT risk factors and lower the chlorpromazine dose if needed.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
