Drug interactions
Chlorpromazine + Erythromycin lactobionate
Severity: Major
Chlorpromazine and Erythromycin lactobionate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin prolongs the QT interval, and chlorpromazine adds to this, increasing the risk of torsades de pointes. Intravenous dosing gives high peak concentrations, so the risk is notable.
What this interaction means in plain words
Chlorpromazine and Erythromycin lactobionate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpromazine belongs to Central Nervous System; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Additive QT prolongation, with possible CYP3A4 inhibition by erythromycin.
What to do
Consider an alternative antibiotic. If the combination is needed, monitor ECG and electrolytes and infuse erythromycin slowly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Erythromycin lactobionate?
MediHelp rates the interaction as major. Chlorpromazine and Erythromycin lactobionate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intravenous erythromycin prolongs the QT interval, and chlorpromazine adds to this, increasing the risk of torsades de pointes. Intravenous dosing gives high peak concentrations, so the risk is notable.
How serious is the interaction between Chlorpromazine and Erythromycin lactobionate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic. If the combination is needed, monitor ECG and electrolytes and infuse erythromycin slowly.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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