Drug interactions
Chlorpromazine + Fenfluramine
Severity: Moderate
Chlorpromazine and Fenfluramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine can cause somnolence and chlorpromazine is sedating, so CNS effects may be additive. Both may affect heart rate and rhythm and fenfluramine carries valvular and pulmonary hypertension warnings.
What this interaction means in plain words
Chlorpromazine and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Fenfluramine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; also serotonergic and dopaminergic pharmacodynamic interplay of uncertain significance.
What to do
Monitor sedation and cardiovascular status, including echocardiography as required by fenfluramine labeling. Consider an ECG if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Chlorpromazine with Fenfluramine?
MediHelp rates the interaction as moderate. Chlorpromazine and Fenfluramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenfluramine can cause somnolence and chlorpromazine is sedating, so CNS effects may be additive. Both may affect heart rate and rhythm and fenfluramine carries valvular and pulmonary hypertension warnings.
How serious is the interaction between Chlorpromazine and Fenfluramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and cardiovascular status, including echocardiography as required by fenfluramine labeling. Consider an ECG if other QT risk factors are present.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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