Drug interactions
Chlorpromazine + Goserelin
Severity: Moderate
Chlorpromazine and Goserelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with goserelin can prolong the QT interval. With chlorpromazine, which also prolongs QT, the risk of torsades de pointes may increase, especially with other risk factors.
What this interaction means in plain words
Chlorpromazine and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Goserelin belongs to Endocrine.
Why it happens
Additive QT prolongation from androgen deprivation and phenothiazine effects.
What to do
Obtain a baseline ECG and periodic QTc monitoring, and correct electrolyte abnormalities. Consider an alternative to chlorpromazine if QTc is substantially prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Goserelin
Frequently asked questions
Can I take Chlorpromazine with Goserelin?
MediHelp rates the interaction as moderate. Chlorpromazine and Goserelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with goserelin can prolong the QT interval. With chlorpromazine, which also prolongs QT, the risk of torsades de pointes may increase, especially with other risk factors.
How serious is the interaction between Chlorpromazine and Goserelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and periodic QTc monitoring, and correct electrolyte abnormalities. Consider an alternative to chlorpromazine if QTc is substantially prolonged.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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