Drug interactions
Chlorpromazine + Insulin degludec-insulin aspart
Severity: Moderate
Chlorpromazine and Insulin degludec-insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine can raise blood glucose and impair glucose tolerance, reducing the effect of insulin. Higher insulin doses may be needed in diabetic patients.
What this interaction means in plain words
Chlorpromazine and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Insulin degludec-insulin aspart belongs to Endocrine.
Why it happens
Phenothiazines may reduce insulin secretion and sensitivity, antagonizing insulin pharmacodynamically.
What to do
Monitor blood glucose when chlorpromazine is started, stopped or adjusted, and titrate the insulin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Insulin degludec-insulin aspart?
MediHelp rates the interaction as moderate. Chlorpromazine and Insulin degludec-insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine can raise blood glucose and impair glucose tolerance, reducing the effect of insulin. Higher insulin doses may be needed in diabetic patients.
How serious is the interaction between Chlorpromazine and Insulin degludec-insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when chlorpromazine is started, stopped or adjusted, and titrate the insulin dose accordingly.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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