Drug interactions
Chlorpromazine + Methamphetamine
Severity: Moderate
Chlorpromazine and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine blocks dopamine and adrenergic receptors and can reduce the stimulant effects of methamphetamine, and it is sometimes used to treat stimulant toxicity. Both drugs can affect heart rhythm and blood pressure, and chlorpromazine can prolong the QT interval, so arrhythmia risk may rise in predisposed patients.
What this interaction means in plain words
Chlorpromazine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Methamphetamine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine and alpha-adrenergic receptors, with additive cardiac effects including QT prolongation.
What to do
Monitor ECG, blood pressure and heart rate in patients with cardiac risk factors or electrolyte abnormalities. Correct potassium and magnesium and avoid additional QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Methamphetamine?
MediHelp rates the interaction as moderate. Chlorpromazine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine blocks dopamine and adrenergic receptors and can reduce the stimulant effects of methamphetamine, and it is sometimes used to treat stimulant toxicity. Both drugs can affect heart rhythm and blood pressure, and chlorpromazine can prolong the QT interval, so arrhythmia risk may rise in predisposed patients.
How serious is the interaction between Chlorpromazine and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, blood pressure and heart rate in patients with cardiac risk factors or electrolyte abnormalities. Correct potassium and magnesium and avoid additional QT-prolonging drugs.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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