Drug interactions
Chlorpromazine + Midodrine
Severity: Moderate
Chlorpromazine and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine raises blood pressure through alpha-1 agonism, while chlorpromazine blocks alpha-1 receptors and can cause orthostatic hypotension, so the two have opposing effects. The result can be reduced midodrine efficacy and unpredictable blood pressure responses.
What this interaction means in plain words
Chlorpromazine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Midodrine belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism at alpha-1 adrenergic receptors.
What to do
Monitor supine and standing blood pressure and adjust the midodrine dose if the response is blunted. Review whether chlorpromazine is essential in patients with orthostatic hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpromazine and Midodrine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Chlorpromazine with Midodrine?
MediHelp rates the interaction as moderate. Chlorpromazine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midodrine raises blood pressure through alpha-1 agonism, while chlorpromazine blocks alpha-1 receptors and can cause orthostatic hypotension, so the two have opposing effects. The result can be reduced midodrine efficacy and unpredictable blood pressure responses.
How serious is the interaction between Chlorpromazine and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor supine and standing blood pressure and adjust the midodrine dose if the response is blunted. Review whether chlorpromazine is essential in patients with orthostatic hypotension.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
