Drug interactions
Chlorpromazine + Mirtazapine
Severity: Moderate
Chlorpromazine and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine prolongs the QT interval, and mirtazapine may add to this, particularly at higher doses. Additive sedation, hypotension and anticholinergic effects may also occur.
What this interaction means in plain words
Chlorpromazine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation and additive CNS depressant effects.
What to do
Obtain a baseline ECG and correct electrolytes. Monitor QTc, sedation and orthostatic blood pressure, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Mirtazapine?
MediHelp rates the interaction as moderate. Chlorpromazine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine prolongs the QT interval, and mirtazapine may add to this, particularly at higher doses. Additive sedation, hypotension and anticholinergic effects may also occur.
How serious is the interaction between Chlorpromazine and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes. Monitor QTc, sedation and orthostatic blood pressure, especially in older patients.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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