Drug interactions
Chlorpromazine + Modafinil
Severity: Moderate
Chlorpromazine and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine is a sedating antipsychotic and modafinil is a wake-promoting agent, so they have opposing effects on alertness. Modafinil may also worsen psychiatric symptoms such as anxiety, agitation or psychosis in susceptible patients on antipsychotics.
What this interaction means in plain words
Chlorpromazine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Modafinil belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on arousal; dopamine antagonism versus dopamine reuptake inhibition.
What to do
Monitor psychiatric status and sedation, and reassess the need for modafinil if psychotic symptoms emerge or worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Modafinil?
MediHelp rates the interaction as moderate. Chlorpromazine and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine is a sedating antipsychotic and modafinil is a wake-promoting agent, so they have opposing effects on alertness. Modafinil may also worsen psychiatric symptoms such as anxiety, agitation or psychosis in susceptible patients on antipsychotics.
How serious is the interaction between Chlorpromazine and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor psychiatric status and sedation, and reassess the need for modafinil if psychotic symptoms emerge or worsen.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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