Drug interactions
Chlorpromazine + Ozanimod
Severity: Moderate
Chlorpromazine and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine can prolong the QT interval and ozanimod can slow heart rate at treatment initiation. Bradycardia increases the likelihood of torsades de pointes in patients receiving QT-prolonging drugs.
What this interaction means in plain words
Chlorpromazine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Ozanimod belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect: chlorpromazine blocks cardiac potassium channels while ozanimod causes S1P-mediated heart rate slowing that favors arrhythmia.
What to do
Obtain a baseline ECG and avoid starting ozanimod in patients on QT-prolonging drugs unless the benefit outweighs the risk, ideally after cardiology input. Correct potassium and magnesium and monitor heart rate and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Ozanimod?
MediHelp rates the interaction as moderate. Chlorpromazine and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine can prolong the QT interval and ozanimod can slow heart rate at treatment initiation. Bradycardia increases the likelihood of torsades de pointes in patients receiving QT-prolonging drugs.
How serious is the interaction between Chlorpromazine and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and avoid starting ozanimod in patients on QT-prolonging drugs unless the benefit outweighs the risk, ideally after cardiology input. Correct potassium and magnesium and monitor heart rate and ECG.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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