Drug interactions
Chlorpromazine + Risperidone
Severity: Major
Chlorpromazine and Risperidone: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining these antipsychotics increases the risk of QT prolongation, extrapyramidal symptoms, sedation and neuroleptic malignant syndrome. Chlorpromazine may also inhibit CYP2D6 and raise risperidone exposure.
What this interaction means in plain words
Chlorpromazine and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpromazine belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation and D2 blockade, plus CYP2D6 inhibition by chlorpromazine that raises risperidone levels.
What to do
Avoid the combination if possible; otherwise use the lowest doses, obtain an ECG, correct electrolytes, and monitor for movement disorders and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Chlorpromazine with Risperidone?
MediHelp rates the interaction as major. Chlorpromazine and Risperidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining these antipsychotics increases the risk of QT prolongation, extrapyramidal symptoms, sedation and neuroleptic malignant syndrome. Chlorpromazine may also inhibit CYP2D6 and raise risperidone exposure.
How serious is the interaction between Chlorpromazine and Risperidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise use the lowest doses, obtain an ECG, correct electrolytes, and monitor for movement disorders and sedation.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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