Drug interactions
Chlorpromazine + Sevoflurane
Severity: Moderate
Chlorpromazine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane can prolong the QT interval, and chlorpromazine adds to this effect, which may increase perioperative arrhythmia risk. Additive hypotension and CNS depression are also expected.
What this interaction means in plain words
Chlorpromazine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus additive vasodilatory and central depressant effects.
What to do
Inform the anesthesia team of chlorpromazine use, correct electrolytes beforehand and monitor ECG and blood pressure during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Sevoflurane
Frequently asked questions
Can I take Chlorpromazine with Sevoflurane?
MediHelp rates the interaction as moderate. Chlorpromazine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane can prolong the QT interval, and chlorpromazine adds to this effect, which may increase perioperative arrhythmia risk. Additive hypotension and CNS depression are also expected.
How serious is the interaction between Chlorpromazine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of chlorpromazine use, correct electrolytes beforehand and monitor ECG and blood pressure during anesthesia.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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