Drug interactions
Chlorpromazine + Stiripentol
Severity: Moderate
Chlorpromazine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so combined use can lead to marked somnolence and impaired alertness. Stiripentol also inhibits several CYP enzymes and may raise chlorpromazine concentrations.
What this interaction means in plain words
Chlorpromazine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression plus possible CYP inhibition by stiripentol.
What to do
Monitor for oversedation and consider reducing the chlorpromazine dose. Advise avoidance of alcohol and caution with driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Chlorpromazine with Stiripentol?
MediHelp rates the interaction as moderate. Chlorpromazine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so combined use can lead to marked somnolence and impaired alertness. Stiripentol also inhibits several CYP enzymes and may raise chlorpromazine concentrations.
How serious is the interaction between Chlorpromazine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and consider reducing the chlorpromazine dose. Advise avoidance of alcohol and caution with driving.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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