Drug interactions
Chlorpromazine + Tiotropium-olodaterol
Severity: Moderate
Chlorpromazine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine has anticholinergic activity that adds to tiotropium, increasing dry mouth, urinary retention, constipation and blurred vision. It also prolongs the QT interval, and beta2 stimulation by olodaterol may add to arrhythmia risk, particularly with hypokalemia.
What this interaction means in plain words
Chlorpromazine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive anticholinergic effects and additive QT prolongation with beta2-mediated sympathetic stimulation.
What to do
Monitor for anticholinergic adverse effects and obtain an ECG in patients with cardiac risk factors. Keep potassium and magnesium within normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpromazine and Tiotropium-olodaterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tiotropium-olodaterol
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Chlorpromazine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine has anticholinergic activity that adds to tiotropium, increasing dry mouth, urinary retention, constipation and blurred vision. It also prolongs the QT interval, and beta2 stimulation by olodaterol may add to arrhythmia risk, particularly with hypokalemia.
How serious is the interaction between Chlorpromazine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and obtain an ECG in patients with cardiac risk factors. Keep potassium and magnesium within normal range.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
