Drug interactions
Chlorpromazine + Trimipramine
Severity: Major
Chlorpromazine and Trimipramine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and chlorpromazine also inhibits CYP2D6, which may raise tricyclic concentrations. Together they add to the risk of torsades de pointes, and additive sedation, anticholinergic effects and hypotension are also expected.
What this interaction means in plain words
Chlorpromazine and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpromazine belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Additive QT prolongation with pharmacokinetic CYP2D6 inhibition by chlorpromazine, plus additive anticholinergic and sedative effects.
What to do
Avoid the combination where possible. If it is essential, obtain a baseline and follow-up ECG, correct potassium and magnesium, and monitor for anticholinergic effects and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Trimipramine?
MediHelp rates the interaction as major. Chlorpromazine and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and chlorpromazine also inhibits CYP2D6, which may raise tricyclic concentrations. Together they add to the risk of torsades de pointes, and additive sedation, anticholinergic effects and hypotension are also expected.
How serious is the interaction between Chlorpromazine and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is essential, obtain a baseline and follow-up ECG, correct potassium and magnesium, and monitor for anticholinergic effects and sedation.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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