Drug interactions
Chlorpromazine + Valbenazine
Severity: Moderate
Chlorpromazine and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine can inhibit CYP2D6 and may raise exposure to the active metabolite of valbenazine, increasing dose-related adverse effects such as somnolence and parkinsonism. Both drugs can also prolong the QT interval, so the combination adds to arrhythmia risk.
What this interaction means in plain words
Chlorpromazine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Chlorpromazine inhibits CYP2D6-mediated metabolism of valbenazine's active metabolite, and both agents have additive QT-prolonging effects.
What to do
Monitor for sedation, extrapyramidal symptoms and QTc prolongation, and consider lowering the valbenazine dose if tolerability is poor. Correct electrolyte abnormalities and obtain an ECG in patients with additional QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Chlorpromazine with Valbenazine?
MediHelp rates the interaction as moderate. Chlorpromazine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine can inhibit CYP2D6 and may raise exposure to the active metabolite of valbenazine, increasing dose-related adverse effects such as somnolence and parkinsonism. Both drugs can also prolong the QT interval, so the combination adds to arrhythmia risk.
How serious is the interaction between Chlorpromazine and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, extrapyramidal symptoms and QTc prolongation, and consider lowering the valbenazine dose if tolerability is poor. Correct electrolyte abnormalities and obtain an ECG in patients with additional QT risk factors.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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