Drug interactions
Chlorpromazine + Vortioxetine
Severity: Moderate
Chlorpromazine and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine inhibits CYP2D6, the main enzyme clearing vortioxetine, which can raise vortioxetine levels and increase nausea and other adverse effects. Both drugs also have additive effects on serotonergic and sedative pathways.
What this interaction means in plain words
Chlorpromazine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Vortioxetine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated metabolism of vortioxetine increases its plasma concentrations.
What to do
Monitor for vortioxetine adverse effects and consider reducing its dose, as labeling suggests halving for strong CYP2D6 inhibitors. Return to the usual dose if chlorpromazine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Vortioxetine?
MediHelp rates the interaction as moderate. Chlorpromazine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine inhibits CYP2D6, the main enzyme clearing vortioxetine, which can raise vortioxetine levels and increase nausea and other adverse effects. Both drugs also have additive effects on serotonergic and sedative pathways.
How serious is the interaction between Chlorpromazine and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for vortioxetine adverse effects and consider reducing its dose, as labeling suggests halving for strong CYP2D6 inhibitors. Return to the usual dose if chlorpromazine is stopped.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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