Drug interactions
Cholecalciferol + Magnesium hydroxide
Severity: Moderate
Cholecalciferol and Magnesium hydroxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vitamin D enhances intestinal magnesium absorption, and in renal impairment magnesium may accumulate. Hypermagnesemia can cause weakness, hypotension and cardiac conduction problems.
What this interaction means in plain words
Cholecalciferol and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholecalciferol belongs to Musculoskeletal; Magnesium hydroxide belongs to Gastrointestinal Tract.
Why it happens
Vitamin D increases gastrointestinal magnesium absorption, while reduced renal excretion permits accumulation.
What to do
Avoid regular magnesium antacids or laxatives in patients with chronic kidney disease taking vitamin D; monitor serum magnesium if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cholecalciferol
- Cholecalciferol + Digoxin Major
- Aluminum hydroxide + Cholecalciferol Moderate
- Calcium acetate + Cholecalciferol Moderate
- Calcium Carbonate + Cholecalciferol Moderate
- Calcium chloride + Cholecalciferol Moderate
- Calcium citrate + Cholecalciferol Moderate
Other interactions of Magnesium hydroxide
Frequently asked questions
Can I take Cholecalciferol with Magnesium hydroxide?
MediHelp rates the interaction as moderate. Cholecalciferol and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vitamin D enhances intestinal magnesium absorption, and in renal impairment magnesium may accumulate. Hypermagnesemia can cause weakness, hypotension and cardiac conduction problems.
How serious is the interaction between Cholecalciferol and Magnesium hydroxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular magnesium antacids or laxatives in patients with chronic kidney disease taking vitamin D; monitor serum magnesium if needed.
What other medicines interact with Cholecalciferol?
MediHelp also lists interactions of Cholecalciferol with, for example, Digoxin, Aluminum hydroxide, Calcium acetate. The full list is on the Cholecalciferol page.
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