Drug interactions
Ciclesonide + Crizotinib
Severity: Minor
Ciclesonide and Crizotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A4 inhibitor and may increase exposure to ciclesonide's active metabolite. This could lead to systemic corticosteroid effects with prolonged use.
What this interaction means in plain words
Ciclesonide and Crizotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciclesonide belongs to Respiratory; Crizotinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by crizotinib reduces ciclesonide metabolism.
What to do
No routine change; monitor for signs of corticosteroid excess during prolonged coadministration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Apalutamide + Ciclesonide Moderate
- Atazanavir + Ciclesonide Moderate
- Ceritinib + Ciclesonide Moderate
- Ciclesonide + Clarithromycin Moderate
- Ciclesonide + Cobicistat Moderate
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Ciclesonide with Crizotinib?
MediHelp rates the interaction as minor. Ciclesonide and Crizotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crizotinib is a moderate CYP3A4 inhibitor and may increase exposure to ciclesonide's active metabolite. This could lead to systemic corticosteroid effects with prolonged use.
How serious is the interaction between Ciclesonide and Crizotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change; monitor for signs of corticosteroid excess during prolonged coadministration.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Apalutamide, Atazanavir. The full list is on the Ciclesonide page.
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