Drug interactions
Ciclesonide + Itraconazole
Severity: Moderate
Ciclesonide and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole strongly inhibits CYP3A4 and can raise exposure to ciclesonide's active metabolite. This may increase the risk of systemic corticosteroid effects such as adrenal suppression during prolonged use.
What this interaction means in plain words
Ciclesonide and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciclesonide belongs to Respiratory; Itraconazole belongs to Anti Fungals.
Why it happens
CYP3A4 inhibition by itraconazole reduces metabolism of ciclesonide and its active metabolite.
What to do
Monitor for Cushingoid features and adrenal suppression with prolonged use, and consider an alternative inhaled steroid such as beclometasone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Apalutamide + Ciclesonide Moderate
- Atazanavir + Ciclesonide Moderate
- Ceritinib + Ciclesonide Moderate
- Ciclesonide + Clarithromycin Moderate
- Ciclesonide + Cobicistat Moderate
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Ciclesonide with Itraconazole?
MediHelp rates the interaction as moderate. Ciclesonide and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole strongly inhibits CYP3A4 and can raise exposure to ciclesonide's active metabolite. This may increase the risk of systemic corticosteroid effects such as adrenal suppression during prolonged use.
How serious is the interaction between Ciclesonide and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for Cushingoid features and adrenal suppression with prolonged use, and consider an alternative inhaled steroid such as beclometasone.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Apalutamide, Atazanavir. The full list is on the Ciclesonide page.
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