Drug interactions
Ciclesonide + Lonafarnib
Severity: Moderate
Ciclesonide and Lonafarnib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a strong CYP3A inhibitor and may increase exposure to the active metabolite of ciclesonide. This could raise the risk of systemic corticosteroid effects with prolonged use.
What this interaction means in plain words
Ciclesonide and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciclesonide belongs to Respiratory; Lonafarnib belongs to Miscellaneous.
Why it happens
Lonafarnib inhibits CYP3A4, reducing clearance of ciclesonide and its active metabolite.
What to do
Monitor for systemic corticosteroid effects such as Cushingoid features and adrenal suppression. Consider an alternative inhaled corticosteroid for long-term co-use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Apalutamide + Ciclesonide Moderate
- Atazanavir + Ciclesonide Moderate
- Ceritinib + Ciclesonide Moderate
- Ciclesonide + Clarithromycin Moderate
- Ciclesonide + Cobicistat Moderate
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Ciclesonide with Lonafarnib?
MediHelp rates the interaction as moderate. Ciclesonide and Lonafarnib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lonafarnib is a strong CYP3A inhibitor and may increase exposure to the active metabolite of ciclesonide. This could raise the risk of systemic corticosteroid effects with prolonged use.
How serious is the interaction between Ciclesonide and Lonafarnib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for systemic corticosteroid effects such as Cushingoid features and adrenal suppression. Consider an alternative inhaled corticosteroid for long-term co-use.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Apalutamide, Atazanavir. The full list is on the Ciclesonide page.
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