Drug interactions
Ciclesonide + Ribociclib
Severity: Minor
Ciclesonide and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate to strong CYP3A4 inhibitor and may raise exposure to the active metabolite of ciclesonide. Because inhaled ciclesonide has low systemic bioavailability, the increase is expected to be small, though prolonged use could add to systemic corticosteroid effects.
What this interaction means in plain words
Ciclesonide and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ciclesonide belongs to Respiratory; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, reducing the metabolic clearance of ciclesonide and its active metabolite.
What to do
No dose change is usually needed for inhaled ciclesonide. Watch for signs of systemic corticosteroid excess such as Cushingoid features or adrenal suppression during long-term co-use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ciclesonide and Ribociclib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Apalutamide + Ciclesonide Moderate
- Atazanavir + Ciclesonide Moderate
- Ceritinib + Ciclesonide Moderate
- Ciclesonide + Clarithromycin Moderate
- Ciclesonide + Cobicistat Moderate
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Ciclesonide with Ribociclib?
MediHelp rates the interaction as minor. Ciclesonide and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ribociclib is a moderate to strong CYP3A4 inhibitor and may raise exposure to the active metabolite of ciclesonide. Because inhaled ciclesonide has low systemic bioavailability, the increase is expected to be small, though prolonged use could add to systemic corticosteroid effects.
How serious is the interaction between Ciclesonide and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed for inhaled ciclesonide. Watch for signs of systemic corticosteroid excess such as Cushingoid features or adrenal suppression during long-term co-use.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Apalutamide, Atazanavir. The full list is on the Ciclesonide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
