Drug interactions
Ciclesonide + Voriconazole
Severity: Moderate
Ciclesonide and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4 and can raise systemic exposure to inhaled ciclesonide's active metabolite. Prolonged co-use may produce systemic corticosteroid effects including adrenal suppression.
What this interaction means in plain words
Ciclesonide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciclesonide belongs to Respiratory; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated metabolism of ciclesonide increases systemic exposure.
What to do
Monitor for signs of corticosteroid excess and adrenal suppression if used long term. Consider switching to an inhaled steroid less dependent on CYP3A4 if prolonged azole therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Apalutamide + Ciclesonide Moderate
- Atazanavir + Ciclesonide Moderate
- Ceritinib + Ciclesonide Moderate
- Ciclesonide + Clarithromycin Moderate
- Ciclesonide + Cobicistat Moderate
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Ciclesonide with Voriconazole?
MediHelp rates the interaction as moderate. Ciclesonide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole inhibits CYP3A4 and can raise systemic exposure to inhaled ciclesonide's active metabolite. Prolonged co-use may produce systemic corticosteroid effects including adrenal suppression.
How serious is the interaction between Ciclesonide and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess and adrenal suppression if used long term. Consider switching to an inhaled steroid less dependent on CYP3A4 if prolonged azole therapy is needed.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Apalutamide, Atazanavir. The full list is on the Ciclesonide page.
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