Drug interactions
Cidofovir + Lomustine
Severity: Moderate
Cidofovir and Lomustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomustine causes delayed and cumulative myelosuppression, and cidofovir may add neutropenia. Combining them can increase the risk of serious infection or bleeding from low blood counts.
What this interaction means in plain words
Cidofovir and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cidofovir belongs to Anti Virals; Lomustine belongs to Oncology.
Why it happens
Additive bone marrow suppression (pharmacodynamic).
What to do
Check complete blood counts frequently, including during the weeks after lomustine dosing when the nadir occurs. Adjust doses or delay treatment for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cidofovir
- Amikacin + Cidofovir Contraindicated
- Amphotericin b deoxycholate + Cidofovir Contraindicated
- Amphotericin b + Cidofovir Contraindicated
- Bacitracin + Cidofovir Contraindicated
- Capreomycin + Cidofovir Contraindicated
- Cephaloridine + Cidofovir Contraindicated
Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Cidofovir with Lomustine?
MediHelp rates the interaction as moderate. Cidofovir and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomustine causes delayed and cumulative myelosuppression, and cidofovir may add neutropenia. Combining them can increase the risk of serious infection or bleeding from low blood counts.
How serious is the interaction between Cidofovir and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check complete blood counts frequently, including during the weeks after lomustine dosing when the nadir occurs. Adjust doses or delay treatment for significant cytopenias.
What other medicines interact with Cidofovir?
MediHelp also lists interactions of Cidofovir with, for example, Amikacin, Amphotericin b deoxycholate, Amphotericin b. The full list is on the Cidofovir page.
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