Drug interactions
Cidofovir + Pacritinib
Severity: Moderate
Cidofovir and Pacritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib inhibits organic cation transporters, and cidofovir is taken up into tubular cells by organic anion transporters. A transporter interaction with cidofovir is not well established, so the clinical effect is uncertain.
What this interaction means in plain words
Cidofovir and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cidofovir belongs to Anti Virals; Pacritinib belongs to Oncology.
Why it happens
Possible transporter inhibition altering cidofovir disposition; not firmly established.
What to do
Monitor renal function and serum creatinine closely, and use standard cidofovir precautions such as probenecid and hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cidofovir
- Amikacin + Cidofovir Contraindicated
- Amphotericin b deoxycholate + Cidofovir Contraindicated
- Amphotericin b + Cidofovir Contraindicated
- Bacitracin + Cidofovir Contraindicated
- Capreomycin + Cidofovir Contraindicated
- Cephaloridine + Cidofovir Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Cidofovir with Pacritinib?
MediHelp rates the interaction as moderate. Cidofovir and Pacritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pacritinib inhibits organic cation transporters, and cidofovir is taken up into tubular cells by organic anion transporters. A transporter interaction with cidofovir is not well established, so the clinical effect is uncertain.
How serious is the interaction between Cidofovir and Pacritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and serum creatinine closely, and use standard cidofovir precautions such as probenecid and hydration.
What other medicines interact with Cidofovir?
MediHelp also lists interactions of Cidofovir with, for example, Amikacin, Amphotericin b deoxycholate, Amphotericin b. The full list is on the Cidofovir page.
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