Drug interactions
Cinacalcet + Givosiran
Severity: Moderate
Cinacalcet and Givosiran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP2D6 activity, and cinacalcet is metabolized in part by CYP2D6. Cinacalcet levels may rise, increasing the risk of hypocalcemia and gastrointestinal adverse effects.
What this interaction means in plain words
Cinacalcet and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Givosiran belongs to Miscellaneous.
Why it happens
Givosiran-associated reduction of CYP2D6 activity decreases cinacalcet clearance.
What to do
Monitor serum calcium and PTH when givosiran is started and reduce the cinacalcet dose if calcium falls or adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Cinacalcet with Givosiran?
MediHelp rates the interaction as moderate. Cinacalcet and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can reduce CYP2D6 activity, and cinacalcet is metabolized in part by CYP2D6. Cinacalcet levels may rise, increasing the risk of hypocalcemia and gastrointestinal adverse effects.
How serious is the interaction between Cinacalcet and Givosiran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH when givosiran is started and reduce the cinacalcet dose if calcium falls or adverse effects appear.
What other medicines interact with Cinacalcet?
MediHelp also lists interactions of Cinacalcet with, for example, Etelcalcetide, Eliglustat, Metoclopramide. The full list is on the Cinacalcet page.
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