Drug interactions
Cinacalcet + Rolapitant
Severity: Moderate
Cinacalcet and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinacalcet is a CYP2D6 substrate and a strong CYP2D6 inhibitor, and is also metabolized by CYP3A4 and CYP1A2. Rolapitant may modestly raise cinacalcet levels, increasing hypocalcemia and gastrointestinal effects.
What this interaction means in plain words
Cinacalcet and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cinacalcet belongs to Miscellaneous; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits CYP2D6, reducing a pathway of cinacalcet metabolism.
What to do
Monitor serum calcium and PTH and adjust the cinacalcet dose if hypocalcemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Cinacalcet
- Cinacalcet + Etelcalcetide Contraindicated
- Cinacalcet + Eliglustat Major
- Cinacalcet + Metoclopramide Major
- Cinacalcet + Metoclopramide intranasal Major
- Cinacalcet + Tamoxifen Major
- Abiraterone + Cinacalcet Moderate
Frequently asked questions
Can I take Cinacalcet with Rolapitant?
MediHelp rates the interaction as moderate. Cinacalcet and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cinacalcet is a CYP2D6 substrate and a strong CYP2D6 inhibitor, and is also metabolized by CYP3A4 and CYP1A2. Rolapitant may modestly raise cinacalcet levels, increasing hypocalcemia and gastrointestinal effects.
How serious is the interaction between Cinacalcet and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium and PTH and adjust the cinacalcet dose if hypocalcemia occurs.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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