Drug interactions
Cisapride + Dolasetron
Severity: Major
Cisapride and Dolasetron: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both cisapride and dolasetron prolong the QT interval, and dolasetron's active metabolite also prolongs PR and QRS intervals. Combined use increases the risk of torsades de pointes and other serious arrhythmias.
What this interaction means in plain words
Cisapride and Dolasetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisapride belongs to Gastrointestinal Tract; Dolasetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation through cardiac ion channel blockade.
What to do
Avoid the combination and choose an antiemetic with less QT effect. If used, monitor ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Frequently asked questions
Can I take Cisapride with Dolasetron?
MediHelp rates the interaction as major. Cisapride and Dolasetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both cisapride and dolasetron prolong the QT interval, and dolasetron's active metabolite also prolongs PR and QRS intervals. Combined use increases the risk of torsades de pointes and other serious arrhythmias.
How serious is the interaction between Cisapride and Dolasetron?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antiemetic with less QT effect. If used, monitor ECG and correct potassium and magnesium.
What other medicines interact with Cisapride?
MediHelp also lists interactions of Cisapride with, for example, Apomorphine, Artemether, Azithromycin. The full list is on the Cisapride page.
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