Drug interactions
Clarithromycin + Felbamate
Severity: Minor
Clarithromycin and Felbamate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Felbamate is partly metabolized by CYP3A4, so clarithromycin could theoretically raise its levels. Felbamate also induces CYP3A4, and no well-documented clinically important interaction exists.
What this interaction means in plain words
Clarithromycin and Felbamate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clarithromycin belongs to Anti Bacterial; Felbamate belongs to Central Nervous System.
Why it happens
Possible CYP3A4 inhibition reducing felbamate clearance, partly offset by felbamate's own induction of CYP3A4.
What to do
No routine adjustment is needed. Monitor for felbamate adverse effects such as nausea, insomnia and dizziness during co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Felbamate
- Felbamate + Ulipristal Major
- Amisulpride + Felbamate Moderate
- Amitriptyline + Felbamate Moderate
- Apalutamide + Felbamate Moderate
- Asenapine + Felbamate Moderate
- Bosentan + Felbamate Moderate
Frequently asked questions
Can I take Clarithromycin with Felbamate?
MediHelp rates the interaction as minor. Clarithromycin and Felbamate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Felbamate is partly metabolized by CYP3A4, so clarithromycin could theoretically raise its levels. Felbamate also induces CYP3A4, and no well-documented clinically important interaction exists.
How serious is the interaction between Clarithromycin and Felbamate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for felbamate adverse effects such as nausea, insomnia and dizziness during co-therapy.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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