Drug interactions
Clarithromycin + Silodosin
Severity: Major
Clarithromycin and Silodosin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin is a strong CYP3A4 and P-glycoprotein inhibitor and is expected to raise silodosin exposure. This increases the risk of orthostatic hypotension and syncope.
What this interaction means in plain words
Clarithromycin and Silodosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Silodosin belongs to Genitourinary.
Why it happens
Clarithromycin inhibits CYP3A4 and P-glycoprotein, increasing silodosin levels.
What to do
Avoid combination, as strong CYP3A4 inhibitors are not recommended with silodosin. Use an alternative antibiotic such as azithromycin if feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Silodosin?
MediHelp rates the interaction as major. Clarithromycin and Silodosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin is a strong CYP3A4 and P-glycoprotein inhibitor and is expected to raise silodosin exposure. This increases the risk of orthostatic hypotension and syncope.
How serious is the interaction between Clarithromycin and Silodosin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination, as strong CYP3A4 inhibitors are not recommended with silodosin. Use an alternative antibiotic such as azithromycin if feasible.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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