Drug interactions
Clevidipine + Silodosin
Severity: Moderate
Clevidipine and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so combined use may cause additive hypotension or orthostatic symptoms. Clevidipine is an intravenous short-acting agent used in monitored settings, so the effect is typically manageable.
What this interaction means in plain words
Clevidipine and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clevidipine belongs to Cardiovascular; Silodosin belongs to Genitourinary.
Why it happens
Additive vasodilation from calcium channel blockade and alpha-1 adrenergic blockade.
What to do
Monitor blood pressure closely during clevidipine titration in patients on silodosin. Titrate to the target blood pressure and watch for orthostasis after transition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Silodosin?
MediHelp rates the interaction as moderate. Clevidipine and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, so combined use may cause additive hypotension or orthostatic symptoms. Clevidipine is an intravenous short-acting agent used in monitored settings, so the effect is typically manageable.
How serious is the interaction between Clevidipine and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during clevidipine titration in patients on silodosin. Titrate to the target blood pressure and watch for orthostasis after transition.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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