Drug interactions
Clofazimine + Dofetilide
Severity: Major
Clofazimine and Dofetilide: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and dofetilide carries a high intrinsic risk of torsades de pointes. Combined use may add substantially to arrhythmia risk.
What this interaction means in plain words
Clofazimine and Dofetilide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clofazimine belongs to Anti Bacterial; Dofetilide belongs to Cardiovascular.
Why it happens
Additive prolongation of cardiac repolarization through QT-prolonging effects.
What to do
Avoid the combination where possible. If unavoidable, obtain baseline and serial ECGs and keep potassium and magnesium within normal ranges.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clofazimine
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Clofazimine with Dofetilide?
MediHelp rates the interaction as major. Clofazimine and Dofetilide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and dofetilide carries a high intrinsic risk of torsades de pointes. Combined use may add substantially to arrhythmia risk.
How serious is the interaction between Clofazimine and Dofetilide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If unavoidable, obtain baseline and serial ECGs and keep potassium and magnesium within normal ranges.
What other medicines interact with Clofazimine?
MediHelp also lists interactions of Clofazimine with, for example, Adagrasib, Amisulpride, Azithromycin. The full list is on the Clofazimine page.
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