Drug interactions
Clomipramine + Dexmethylphenidate
Severity: Moderate
Clomipramine and Dexmethylphenidate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may raise methylphenidate-class drug levels and both increase noradrenergic activity, which can lead to hypertension, tachycardia and arrhythmia. Seizure threshold may also be lowered.
What this interaction means in plain words
Clomipramine and Dexmethylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Dexmethylphenidate belongs to Central Nervous System.
Why it happens
Additive noradrenergic reuptake inhibition, with possible reduced metabolism of dexmethylphenidate by the tricyclic.
What to do
Monitor blood pressure, heart rate and ECG when co-prescribed, and use the lowest effective doses. Reduce the dexmethylphenidate dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Dexmethylphenidate
- Dexmethylphenidate + Isocarboxazid Contraindicated
- Dexmethylphenidate + Linezolid Contraindicated
- Dexmethylphenidate + Phenelzine Contraindicated
- Dexmethylphenidate + Procarbazine Contraindicated
- Dexmethylphenidate + Rasagiline Contraindicated
- Dexmethylphenidate + Safinamide Contraindicated
Frequently asked questions
Can I take Clomipramine with Dexmethylphenidate?
MediHelp rates the interaction as moderate. Clomipramine and Dexmethylphenidate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants may raise methylphenidate-class drug levels and both increase noradrenergic activity, which can lead to hypertension, tachycardia and arrhythmia. Seizure threshold may also be lowered.
How serious is the interaction between Clomipramine and Dexmethylphenidate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG when co-prescribed, and use the lowest effective doses. Reduce the dexmethylphenidate dose if adverse effects occur.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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