Drug interactions
Clomipramine + Givosiran
Severity: Moderate
Clomipramine and Givosiran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce activity of CYP1A2 and CYP2D6, both of which metabolize clomipramine. Clomipramine levels may rise, increasing risk of tricyclic toxicity.
What this interaction means in plain words
Clomipramine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Givosiran belongs to Miscellaneous.
Why it happens
Givosiran inhibits CYP1A2 and CYP2D6, decreasing clomipramine clearance.
What to do
Monitor for anticholinergic effects, sedation and ECG changes, and reduce the clomipramine dose if needed. Consider plasma level monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Clomipramine with Givosiran?
MediHelp rates the interaction as moderate. Clomipramine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can reduce activity of CYP1A2 and CYP2D6, both of which metabolize clomipramine. Clomipramine levels may rise, increasing risk of tricyclic toxicity.
How serious is the interaction between Clomipramine and Givosiran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, sedation and ECG changes, and reduce the clomipramine dose if needed. Consider plasma level monitoring.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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