Drug interactions
Colchicine + Elagolix
Severity: Moderate
Colchicine and Elagolix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix inhibits P-glycoprotein, which may increase colchicine exposure, and it also induces CYP3A4, which may lower it. The net effect is unpredictable, but because colchicine has a narrow therapeutic index, toxicity is the greater concern.
What this interaction means in plain words
Colchicine and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colchicine belongs to Genitourinary; Elagolix belongs to Musculoskeletal.
Why it happens
Opposing effects: P-gp inhibition raises colchicine levels while CYP3A4 induction by elagolix may lower them.
What to do
Monitor for colchicine toxicity and for loss of efficacy, and adjust the colchicine dose according to response, especially in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Colchicine with Elagolix?
MediHelp rates the interaction as moderate. Colchicine and Elagolix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elagolix inhibits P-glycoprotein, which may increase colchicine exposure, and it also induces CYP3A4, which may lower it. The net effect is unpredictable, but because colchicine has a narrow therapeutic index, toxicity is the greater concern.
How serious is the interaction between Colchicine and Elagolix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for colchicine toxicity and for loss of efficacy, and adjust the colchicine dose according to response, especially in renal impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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