Drug interactions
Colchicine + Pacritinib
Severity: Major
Colchicine and Pacritinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib inhibits P-glycoprotein and may raise colchicine concentrations, increasing the risk of colchicine toxicity such as gastrointestinal effects, myelosuppression and neuromuscular toxicity. Colchicine has a narrow therapeutic index, so this matters especially in renal or hepatic impairment.
What this interaction means in plain words
Colchicine and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colchicine belongs to Genitourinary; Pacritinib belongs to Oncology.
Why it happens
Pacritinib inhibits P-glycoprotein efflux of colchicine, increasing its systemic exposure.
What to do
Avoid the combination where possible, or reduce the colchicine dose and monitor closely for toxicity. Avoid it entirely in patients with renal or hepatic impairment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Colchicine with Pacritinib?
MediHelp rates the interaction as major. Colchicine and Pacritinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pacritinib inhibits P-glycoprotein and may raise colchicine concentrations, increasing the risk of colchicine toxicity such as gastrointestinal effects, myelosuppression and neuromuscular toxicity. Colchicine has a narrow therapeutic index, so this matters especially in renal or hepatic impairment.
How serious is the interaction between Colchicine and Pacritinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or reduce the colchicine dose and monitor closely for toxicity. Avoid it entirely in patients with renal or hepatic impairment.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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