Drug interactions
Colesevelam + Glipizide
Severity: Moderate
Colesevelam and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam is a bile acid sequestrant that can bind glipizide in the gut and reduce its absorption. This may weaken glycemic control if the two are taken together.
What this interaction means in plain words
Colesevelam and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Colesevelam belongs to Endocrine; Glipizide belongs to Endocrine.
Why it happens
Colesevelam adsorbs glipizide in the gastrointestinal lumen, reducing its absorption.
What to do
Give glipizide at least 4 hours before colesevelam. Monitor blood glucose if the timing cannot be separated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Glibenclamide Moderate
Frequently asked questions
Can I take Colesevelam with Glipizide?
MediHelp rates the interaction as moderate. Colesevelam and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colesevelam is a bile acid sequestrant that can bind glipizide in the gut and reduce its absorption. This may weaken glycemic control if the two are taken together.
How serious is the interaction between Colesevelam and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give glipizide at least 4 hours before colesevelam. Monitor blood glucose if the timing cannot be separated.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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