Drug interactions
Crizotinib + Hawthorn
Severity: Minor
Crizotinib and Hawthorn: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hawthorn is an herbal product with cardiac activity and has been suggested to affect QT interval, which may add to crizotinib's QT prolongation. Evidence for the interaction is weak.
What this interaction means in plain words
Crizotinib and Hawthorn have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crizotinib belongs to Oncology; Hawthorn belongs to Gastrointestinal Tract.
Why it happens
Theoretical additive effects on cardiac repolarization; the mechanism is not firmly established.
What to do
Advise patients to avoid hawthorn supplements during crizotinib treatment, or obtain an ECG if use continues.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Hawthorn
- Amiodarone + Hawthorn Moderate
- Digoxin + Hawthorn Moderate
- Disopyramide + Hawthorn Moderate
- Encainide + Hawthorn Moderate
- Hawthorn + Ibutilide Moderate
- Hawthorn + Procainamide Moderate
Frequently asked questions
Can I take Crizotinib with Hawthorn?
MediHelp rates the interaction as minor. Crizotinib and Hawthorn have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hawthorn is an herbal product with cardiac activity and has been suggested to affect QT interval, which may add to crizotinib's QT prolongation. Evidence for the interaction is weak.
How serious is the interaction between Crizotinib and Hawthorn?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid hawthorn supplements during crizotinib treatment, or obtain an ECG if use continues.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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