Drug interactions
Crizotinib + Mitomycin
Severity: Minor
Crizotinib and Mitomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib may inhibit P-glycoprotein and theoretically increase mitomycin exposure. Mitomycin's toxicities include myelosuppression and hemolytic uremic syndrome, but the clinical relevance of this interaction is unproven.
What this interaction means in plain words
Crizotinib and Mitomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crizotinib belongs to Oncology; Mitomycin belongs to Oncology.
Why it happens
Possible inhibition of P-glycoprotein-mediated efflux of mitomycin by crizotinib.
What to do
Monitor blood counts and renal function as per standard mitomycin care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Frequently asked questions
Can I take Crizotinib with Mitomycin?
MediHelp rates the interaction as minor. Crizotinib and Mitomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crizotinib may inhibit P-glycoprotein and theoretically increase mitomycin exposure. Mitomycin's toxicities include myelosuppression and hemolytic uremic syndrome, but the clinical relevance of this interaction is unproven.
How serious is the interaction between Crizotinib and Mitomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and renal function as per standard mitomycin care.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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