Drug interactions
Crizotinib + Silodosin
Severity: Moderate
Crizotinib and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib inhibits CYP3A4 and P-glycoprotein, both involved in silodosin disposition, so silodosin concentrations may rise. This can increase orthostatic hypotension, dizziness and other adverse effects.
What this interaction means in plain words
Crizotinib and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Crizotinib belongs to Oncology; Silodosin belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4 metabolism and P-glycoprotein efflux by crizotinib reduces silodosin clearance.
What to do
Monitor for orthostatic hypotension and dizziness and consider reducing silodosin if symptoms appear. Avoid combining if other strong inhibitors are also used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Crizotinib with Silodosin?
MediHelp rates the interaction as moderate. Crizotinib and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib inhibits CYP3A4 and P-glycoprotein, both involved in silodosin disposition, so silodosin concentrations may rise. This can increase orthostatic hypotension, dizziness and other adverse effects.
How serious is the interaction between Crizotinib and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension and dizziness and consider reducing silodosin if symptoms appear. Avoid combining if other strong inhibitors are also used.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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